PAPOLA

Across TCGA cell cohorts, PAPOLA mutation is significantly associated with the mutation status of many other genes, with 5,029 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAPOLA-associated genes across cancer lineages are PHF20, GRIN2B, and NRP1. Each is linked with PAPOLA in more than 3 cancer types. Because this analysis shows association rather than direction, both PAPOLA-to-partner and partner-to-PAPOLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF20 grouped by PAPOLA-low versus PAPOLA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAPOLA→partner) and Y-score (partner→PAPOLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PHF20 →	+3.338	+4.083	.003	.003	1	4
BLOOD_Leukemia	GRIN2B →	+2.653	+4.452	.001	.001	1	4
LUNG_NSCLC_LUAD	NRP1 →	+5.000	+4.187	.008	.008	1	4
BLOOD_Leukemia	ADCY3 →	+2.823	+3.665	.008	.008	1	4
CNS	MEPCE →	+5.614	+5.044	.003	.003	1	4
BLOOD_Leukemia	LTF →	+3.560	+4.247	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,029 associations by consensus.

PHF20 by PAPOLA expression — BLOOD_Leukemia

Explore this box plot interactively →