PAOX

Across TCGA patient cohorts, PAOX RNA expression is significantly associated with the go_rna of many other GO terms, with 7,152 significant associations in total. THCA shows the largest number of these associations.

The most reproducible PAOX-associated GO terms across cancer lineages are Spermine metabolic process, Spermidine metabolic process, and Regulation of amine metabolic process. Each is linked with PAOX in more than 21 cancer types. Because this analysis shows association rather than direction, both PAOX-to-partner and partner-to-PAOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spermine metabolic process grouped by PAOX-low versus PAOX-high in PRAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAOX→partner) and Y-score (partner→PAOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	Spermine metabolic process →	+0.085	+1.026	<.001	<.001	3	22
CHOL	Spermidine metabolic process →	+0.083	+0.890	<.001	<.001	3	21
THYM	Regulation of amine metabolic process →	+0.040	+0.778	<.001	<.001	3	20
OV	Positive regulation of neutrophil activation →	+0.062	+0.279	<.001	<.001	3	20
LAML	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II →	+0.084	+0.704	<.001	<.001	3	19
LAML	Positive regulation of interleukin-12 production →	+0.064	+0.707	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,152 associations by consensus.

Spermine metabolic process by PAOX expression — PRAD

Explore this box plot interactively →