PAOX

Across TCGA patient cohorts, PAOX mutation is significantly associated with the RNA expression of many other genes, with 2,590 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAOX-associated genes across cancer lineages are RPSAP37, RNA5SP469, and RNY4P23. Each is linked with PAOX in more than 1 cancer types. Because this analysis shows association rather than direction, both PAOX-to-partner and partner-to-PAOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPSAP37 grouped by PAOX-low versus PAOX-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAOX→partner) and Y-score (partner→PAOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPSAP37 →	+0.029	+4.282	<.001	.009	3	2
LUAD	RNA5SP469 →	+1.150	+3.659	<.001	.009	3	2
LUAD	RNY4P23 →	+0.758	+3.690	<.001	.009	3	2
LUAD	TAF9BP2 →	+0.415	+4.293	<.001	.003	3	2
LUAD	MIR1302-5 →	+0.472	+4.629	<.001	.001	3	2
LUAD	RNU6-172P →	+1.119	+4.157	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,590 associations by consensus.

RPSAP37 by PAOX expression — SKCM

Explore this box plot interactively →