PAOX

Across TCGA cell cohorts, PAOX mutation is significantly associated with the drug of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAOX-associated genes across cancer lineages are Bromosporine, SGC-CBP30, and RVX-208. Each is linked with PAOX in more than 1 cancer types. Because this analysis shows association rather than direction, both PAOX-to-partner and partner-to-PAOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bromosporine grouped by PAOX-low versus PAOX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAOX→partner) and Y-score (partner→PAOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Bromosporine →	+0.343	+2.649	.046	.046	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.308	+2.649	.029	.046	3	1
LARGE_INTESTINE	RVX-208 →	+0.369	+2.646	.016	.047	3	1
LARGE_INTESTINE	GSK2276186C →	+0.571	+2.649	.012	.046	3	1
LARGE_INTESTINE	alpha-lipoic acid →	+0.355	+2.684	.012	.035	3	1
LARGE_INTESTINE	Oxaliplatin →	+0.535	+2.649	.044	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Bromosporine by PAOX expression — LARGE_INTESTINE

Explore this box plot interactively →