PANX3

Across TCGA pan-cancer cohorts, PANX3 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PANX3 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher PANX3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PANX3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

READ and UCEC are the cancer types where PANX3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	All	0.112	0.845	.001	12	view →
UCEC	OS	Median	All	0.961	0.652	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PANX3–READ (DFS)

Open the READ breakdown →