PANX3

Across TCGA patient cohorts, PANX3 mutation is significantly associated with the RNA expression of many other genes, with 1,971 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PANX3-associated genes across cancer lineages are FANCA, WDHD1, and ATXN2. Each is linked with PANX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PANX3-to-partner and partner-to-PANX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCA grouped by PANX3-low versus PANX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX3→partner) and Y-score (partner→PANX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCA →	+0.574	+2.523	<.001	<.001	3	3
UCEC	WDHD1 →	+0.576	+2.687	.001	<.001	3	3
UCEC	ATXN2 →	+0.367	+2.627	.001	.005	3	3
UCEC	DPP9 →	+0.463	+2.169	<.001	<.001	3	3
UCEC	GPATCH11 →	+0.385	+2.950	.002	<.001	3	3
SKCM	NARS1 →	+0.555	+2.616	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,971 associations by consensus.

FANCA by PANX3 expression — UCEC

Explore this box plot interactively →