PANX3

Across TCGA patient cohorts, PANX3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PANX3-associated genes across cancer lineages are 4E-BP1, JNK_pT183_Y185, and c-Met_pY1235. Each is linked with PANX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANX3-to-partner and partner-to-PANX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PANX3-low versus PANX3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX3→partner) and Y-score (partner→PANX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1 →	+0.397	+2.321	.008	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.167	-1.700	.008	.042	3	2
UCEC	c-Met_pY1235 →	+0.067	+1.415	.016	.046	3	2
UCEC	Cyclin-B1 →	+0.545	+2.321	.009	.033	3	2
LUSC	Rb →	+0.191	+3.594	.035	.001	3	1
LUSC	Bad_pS112 →	-0.152	-2.431	.038	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

4E-BP1 by PANX3 expression — SKCM

Explore this box plot interactively →