PANX3

Across TCGA cell cohorts, PANX3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PANX3-associated genes across cancer lineages are CPN1, GPR42, and PCARE. Each is linked with PANX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANX3-to-partner and partner-to-PANX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPN1 grouped by PANX3-low versus PANX3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX3→partner) and Y-score (partner→PANX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CPN1 →	+0.156	+3.736	<.001	.009	3	1
BLOOD_Lymphoma	GPR42 →	+0.066	+4.606	<.001	.001	3	1
BLOOD_Lymphoma	PCARE →	+0.030	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	SPATA31A6 →	+0.017	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	CYP26C1 →	+0.026	+3.920	.002	.005	3	1
BLOOD_Lymphoma	AMY1C →	+0.029	+3.523	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CPN1 by PANX3 expression — BLOOD_Lymphoma

Explore this box plot interactively →