PANX3

Across TCGA cell cohorts, PANX3 mutation is significantly associated with the mutation status of many other genes, with 3,342 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PANX3-associated genes across cancer lineages are CTTNBP2, LATS1, and NOTCH2. Each is linked with PANX3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PANX3-to-partner and partner-to-PANX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTTNBP2 grouped by PANX3-low versus PANX3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX3→partner) and Y-score (partner→PANX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CTTNBP2 →	+2.284	+3.925	.005	.005	1	5
UPPER_AERODIGESTIVE_TRACT	LATS1 →	+5.392	+5.392	.004	.004	1	4
LARGE_INTESTINE	NOTCH2 →	+2.043	+3.693	.009	.009	1	4
BLOOD_Lymphoma	CCDC171 →	+3.969	+3.969	.002	.002	1	4
UPPER_AERODIGESTIVE_TRACT	TLN2 →	+4.392	+4.954	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	MET →	+5.392	+5.392	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,342 associations by consensus.

CTTNBP2 by PANX3 expression — LARGE_INTESTINE

Explore this box plot interactively →