PANX2

Across TCGA patient cohorts, PANX2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PANX2-associated genes across cancer lineages are ATM, ERK2, and JNK2. Each is linked with PANX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANX2-to-partner and partner-to-PANX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PANX2-low versus PANX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX2→partner) and Y-score (partner→PANX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.474	-2.700	.020	.006	3	2
UCEC	ERK2 →	+0.174	+2.000	.045	.032	3	1
UCEC	JNK2 →	+0.281	+2.179	.001	.034	3	1
UCEC	Ku80 →	+0.282	+2.183	.008	.033	3	1
UCEC	p62 Lck ligand →	+0.305	+2.000	.037	.032	3	1
UCEC	PCNA →	+0.319	+3.321	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ATM by PANX2 expression — UCEC

Explore this box plot interactively →