PANX2

Across TCGA cell cohorts, PANX2 mutation is significantly associated with the RNA expression of many other genes, with 381 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PANX2-associated genes across cancer lineages are BBS7, ZIC5, and OTC. Each is linked with PANX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANX2-to-partner and partner-to-PANX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BBS7 grouped by PANX2-low versus PANX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX2→partner) and Y-score (partner→PANX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BBS7 →	+0.549	+3.364	.008	.002	3	2
LARGE_INTESTINE	ZIC5 →	+1.155	+3.364	<.001	.002	3	2
BLOOD_Leukemia	OTC →	+0.079	+3.266	<.001	.003	3	2
STOMACH	DYNAP →	+0.089	+4.129	.001	.007	3	1
STOMACH	PADI6 →	+0.011	+4.129	<.001	.007	3	1
LARGE_INTESTINE	CBY1 →	+0.627	+3.137	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 381 associations by consensus.

BBS7 by PANX2 expression — LARGE_INTESTINE

Explore this box plot interactively →