PANX1

Across TCGA pan-cancer cohorts, PANX1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PANX1 data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PANX1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PANX1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, UCEC, and HNSC are the cancer types where PANX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.268	0.637	<.001	89	view →
UCEC	DFS	Median	II,III,IV	0.939	0.506	.010	24	view →
HNSC	DFS	Median	All	0.772	0.539	.003	20	view →
GBM	OS	Tertile	All	0.274	0.529	.004	19	view →
COAD	DFS	Median	II,III,IV	0.874	1.000	.016	18	view →
LUAD	OS	Quartile	II,III,IV	0.527	0.828	.032	5	view →
CCRCC	OS	Median	III,IV	0.067	1.000	.036	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PANX1–PDAC (OS)

Open the PDAC breakdown →