PANX1

Across TCGA patient cohorts, PANX1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,316 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PANX1-associated genes across cancer lineages are PLAU, H2AX, and SERPINH1. Each is linked with PANX1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PANX1-to-partner and partner-to-PANX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PANX1 versus PLAU in OV, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX1→partner) and Y-score (partner→PANX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLAU →	+1.334	+0.391	<.001	<.001	3	7
OV	H2AX →	+0.803	+0.371	<.001	<.001	3	6
BRCA	SERPINH1 →	+0.820	+0.594	<.001	<.001	3	6
BRCA	ITGA5 →	+1.138	+0.817	<.001	.001	3	6
OV	CD276 →	+0.659	+0.285	<.001	<.001	3	5
BRCA	DSE →	+0.839	+0.673	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,316 associations by consensus.

PANX1 vs PLAU — OV

Explore this scatter interactively →