PANX1

Across TCGA patient cohorts, PANX1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PANX1-associated genes across cancer lineages are mTOR, Myosin-IIa_pS1943, and Myosin-IIa. Each is linked with PANX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANX1-to-partner and partner-to-PANX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by PANX1-low versus PANX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX1→partner) and Y-score (partner→PANX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.214	-3.169	.006	.018	3	1
UCEC	Myosin-IIa_pS1943 →	+0.272	+2.472	.006	.011	3	1
UCEC	Myosin-IIa →	+0.215	+2.466	.016	.011	3	1
UCEC	PDCD4 →	-0.613	-2.990	.006	.036	3	1
UCEC	TIGAR →	+0.186	+2.486	.011	.011	3	1
UCEC	ATM →	-0.612	-3.584	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

mTOR by PANX1 expression — UCEC

Explore this box plot interactively →