PANX1

Across TCGA cell cohorts, PANX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,060 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PANX1-associated GO terms across cancer lineages are Regulation of protein K48-linked ubiquitination, Regulation of hippo signaling, and Phosphatidylinositol biosynthetic process. Each is linked with PANX1 in more than 16 cancer types. Because this analysis shows association rather than direction, both PANX1-to-partner and partner-to-PANX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein K48-linked ubiquitination grouped by PANX1-low versus PANX1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX1→partner) and Y-score (partner→PANX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of protein K48-linked ubiquitination →	+0.169	+0.958	<.001	<.001	2	17
BONE	Regulation of hippo signaling →	+0.090	+0.903	<.001	<.001	3	13
LUNG_SCLC	Phosphatidylinositol biosynthetic process →	+0.070	+1.119	<.001	<.001	3	13
BREAST	Positive regulation of cell cycle checkpoint →	+0.122	+0.813	<.001	.006	3	13
STOMACH	Regulation of intracellular protein transport →	+0.065	+0.855	<.001	<.001	3	13
STOMACH	Macroautophagy →	+0.062	+0.772	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,060 associations by consensus.

Regulation of protein K48-linked ubiquitination by PANX1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →