PANX1

Across TCGA cell cohorts, PANX1 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PANX1-associated genes across cancer lineages are AVP, OR13C9, and DUXA. Each is linked with PANX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANX1-to-partner and partner-to-PANX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by PANX1-low versus PANX1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX1→partner) and Y-score (partner→PANX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	AVP →	+0.055	+4.981	<.001	.008	3	2
BLOOD_Lymphoma	OR13C9 →	+0.019	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	DUXA →	+0.208	+5.209	<.001	.005	3	1
CNS	IFNA4 →	+0.215	+5.321	<.001	.005	3	1
CNS	C4orf51 →	+0.167	+4.981	.003	.008	3	1
BLOOD_Leukemia	GPR50 →	+0.051	+4.643	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

AVP by PANX1 expression — CNS

Explore this box plot interactively →