PANO1

Across TCGA pan-cancer cohorts, PANO1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PANO1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PANO1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PANO1 is over-expressed in tumor.

COAD, KIRC, and BLCA are the cancer types where PANO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PANO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+1.048	<.001	12	view →
KIRC	All	IV	+0.384	<.001	12	view →
BLCA	All	All	+0.615	<.001	10	view →
KIRP	Female	II,III,IV	+0.686	<.001	9	view →
LIHC	Male	All	+0.373	<.001	9	view →
STAD	Male	II,III,IV	+0.648	<.001	8	view →
HNSC	Male	III,IV	+0.472	<.001	8	view →
THCA	All	All	+0.268	<.001	7	view →
LUSC	Female	II,III,IV	+0.812	<.001	6	view →
UCEC	All	All	+0.690	<.001	6	view →
BRCA	All	III,IV	+0.370	<.001	6	view →
LUAD	Female	All	+0.297	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PANO1–COAD

Open the COAD breakdown →