PANK4

Across TCGA pan-cancer cohorts, PANK4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PANK4 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PANK4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PANK4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, CCRCC, and COAD are the cancer types where PANK4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.249	0.797	.001	28	view →
CCRCC	DFS	Median	II,III,IV	0.805	0.436	<.001	26	view →
COAD	DFS	Median	IV	0.565	1.000	.028	18	view →
PDAC	DFS	Tertile	III,IV	0.507	0.906	.006	12	view →
HNSC	DFS	Median	IV	0.899	0.635	.003	11	view →
GBM	OS	Quartile	All	0.732	0.327	.001	7	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PANK4–LUAD (DFS)

Open the LUAD breakdown →