PANK4

Across TCGA patient cohorts, PANK4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PANK4-associated genes across cancer lineages are Caspase-7-cleavedD198, mTOR_pS2448, and NF2. Each is linked with PANK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PANK4-to-partner and partner-to-PANK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PANK4-low versus PANK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANK4→partner) and Y-score (partner→PANK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.604	+2.019	.007	.017	3	3
UCEC	mTOR_pS2448 →	-0.156	-2.446	.006	.018	3	2
UCEC	NF2 →	+0.222	+2.321	.007	.033	3	2
UCEC	P-Cadherin →	-0.130	-3.169	.018	.018	3	2
UCEC	PCNA →	+0.276	+2.584	<.001	.010	3	2
UCEC	Annexin-1 →	+0.462	+2.019	.022	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Caspase-7-cleavedD198 by PANK4 expression — UCEC

Explore this box plot interactively →