PANK4

Across TCGA cell cohorts, PANK4 mutation is significantly associated with the RNA expression of many other genes, with 261 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PANK4-associated genes across cancer lineages are BTBD16, KSR2, and CRISP1. Each is linked with PANK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANK4-to-partner and partner-to-PANK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTBD16 grouped by PANK4-low versus PANK4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANK4→partner) and Y-score (partner→PANK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BTBD16 →	+0.072	+2.696	<.001	.008	3	2
BLOOD_Leukemia	KSR2 →	+0.310	+3.106	<.001	.002	3	2
PANCREAS	CRISP1 →	+0.009	+3.786	.001	.004	3	1
SKIN	CCDC172 →	+0.006	+5.415	<.001	.004	3	1
SKIN	NPS →	+0.260	+5.415	<.001	.004	3	1
SKIN	OR11H2 →	+0.047	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 261 associations by consensus.

BTBD16 by PANK4 expression — BLOOD_Leukemia

Explore this box plot interactively →