PANK3

Across TCGA pan-cancer cohorts, PANK3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PANK3 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PANK3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PANK3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where PANK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.300	0.620	.002	47	view →
HNSC	DFS	Median	All	0.893	0.677	.001	34	view →
LUAD	DFS	Median	III,IV	0.986	0.579	.003	23	view →
CCRCC	DFS	Quartile	All	1.000	0.254	.006	4	view →
UCEC	OS	Quartile	All	1.000	0.832	.047	2	view →
LSCC	OS	Median	All	0.733	0.869	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PANK3–PDAC (DFS)

Open the PDAC breakdown →