PANK3

Across TCGA pan-cancer cohorts, PANK3 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PANK3’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PANK3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PANK3 is over-expressed in tumor.

LSCC, CCRCC, and PDAC are the cancer types where PANK3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PANK3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	+0.446	<.001	7	view →
CCRCC	All	All	+0.265	.002	4	view →
PDAC	All	All	+0.711	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PANK3–LSCC

Open the LSCC breakdown →