PANK3

Across TCGA patient cohorts, PANK3 mutation is significantly associated with the RNA expression of many other genes, with 1,498 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PANK3-associated genes across cancer lineages are ATP6V1E1P2, RPS10P21, and HMGB3P15. Each is linked with PANK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PANK3-to-partner and partner-to-PANK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP6V1E1P2 grouped by PANK3-low versus PANK3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANK3→partner) and Y-score (partner→PANK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATP6V1E1P2 →	+0.553	+4.611	<.001	.004	3	3
UCEC	RPS10P21 →	+0.179	+1.855	.002	.001	3	2
UCEC	HMGB3P15 →	+0.066	+2.186	<.001	.006	3	2
COAD	RNA5SP358 →	+0.564	+5.251	.008	.003	3	2
STAD	RNU1-57P →	+0.799	+5.026	<.001	.009	3	2
BLCA	RNU6-1191P →	+0.502	+3.472	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,498 associations by consensus.

ATP6V1E1P2 by PANK3 expression — COAD

Explore this box plot interactively →