PANK3

Across TCGA patient cohorts, PANK3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PANK3-associated genes across cancer lineages are A-Raf_pS299, JNK_pT183_Y185, and Notch1. Each is linked with PANK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PANK3-to-partner and partner-to-PANK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PANK3-low versus PANK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANK3→partner) and Y-score (partner→PANK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.132	-2.700	.003	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.129	-1.401	.042	.046	3	2
UCEC	Notch1 →	+0.157	+1.710	.002	.025	3	2
UCEC	C-Raf →	+0.142	+2.000	.008	.030	3	2
UCEC	EGFR_pY1068 →	-0.283	-1.765	.002	.014	3	1
UCEC	FoxM1 →	+0.227	+1.765	.019	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

A-Raf_pS299 by PANK3 expression — UCEC

Explore this box plot interactively →