PANK3

Across TCGA cell cohorts, PANK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,532 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PANK3-associated GO terms across cancer lineages are Heterochromatin formation, Heterochromatin organization, and Epigenetic regulation of gene expression. Each is linked with PANK3 in more than 15 cancer types. Because this analysis shows association rather than direction, both PANK3-to-partner and partner-to-PANK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin formation grouped by PANK3-low versus PANK3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PANK3→partner) and Y-score (partner→PANK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Heterochromatin formation →	+0.085	+0.668	.003	.006	3	16
BONE	Heterochromatin organization →	+0.084	+0.670	.002	.006	3	16
OVARY	Epigenetic regulation of gene expression →	+0.049	+0.744	.001	<.001	3	15
BONE	Negative regulation of gene expression, epigenetic →	+0.089	+0.601	.002	.009	3	15
SOFT_TISSUE	Protein localization to nucleus →	+0.065	+1.000	<.001	<.001	3	15
BLOOD_Myeloma	Positive regulation of mRNA catabolic process →	+0.065	+0.932	<.001	.003	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,532 associations by consensus.

Heterochromatin formation by PANK3 expression — BONE

Explore this box plot interactively →