PANK2

Across TCGA pan-cancer cohorts, PANK2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PANK2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PANK2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PANK2 is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where PANK2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PANK2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−0.418	<.001	9	view →
HNSC	All	IV	−0.284	<.001	9	view →
LSCC	Male	II,III,IV	−0.282	<.001	9	view →
CCRCC	All	All	+0.077	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PANK2–LUAD

Open the LUAD breakdown →