PANDAR

Across TCGA pan-cancer cohorts, PANDAR RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PANDAR’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PANDAR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PANDAR is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

THCA, BRCA, and KIRC are the cancer types where PANDAR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PANDAR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	+0.018	.015	3	view →
BRCA	All	III,IV	+0.015	.018	2	view →
KIRC	Male	II,III,IV	−0.011	.012	2	view →
CHOL	All	All	+0.035	.007	1	view →
KIRP	All	All	−0.012	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PANDAR–THCA

Open the THCA breakdown →