PAN2

Across TCGA patient cohorts, PAN2 mutation is significantly associated with the RNA expression of many other genes, with 3,290 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAN2-associated genes across cancer lineages are NDUFAF2, ZNHIT3, and GTF2F2. Each is linked with PAN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PAN2-to-partner and partner-to-PAN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF2 grouped by PAN2-low versus PAN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAN2→partner) and Y-score (partner→PAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF2 →	+0.540	+2.402	<.001	<.001	3	4
UCEC	ZNHIT3 →	+0.352	+1.709	.001	<.001	3	3
UCEC	GTF2F2 →	+0.348	+1.880	.003	.004	3	3
UCEC	LIN54 →	+0.483	+2.425	<.001	<.001	3	3
UCEC	MIRLET7BHG →	+0.294	+2.021	.006	.005	3	3
BLCA	NCAPG →	+0.892	+3.035	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,290 associations by consensus.

NDUFAF2 by PAN2 expression — UCEC

Explore this box plot interactively →