PAN2

Across TCGA patient cohorts, PAN2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAN2-associated genes across cancer lineages are PCNA, 4E-BP1, and JNK2. Each is linked with PAN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAN2-to-partner and partner-to-PAN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PAN2-low versus PAN2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAN2→partner) and Y-score (partner→PAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PCNA →	+0.219	+2.321	.006	.033	3	3
UCEC	4E-BP1 →	+0.328	+1.893	<.001	<.001	3	2
UCEC	JNK2 →	+0.194	+1.201	.001	.028	3	2
UCEC	MAPK_pT202_Y204 →	-0.305	-1.201	.036	.028	3	2
UCEC	MSH2 →	-0.257	-2.143	<.001	.002	3	2
UCEC	MSH6 →	-0.402	-1.678	<.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PCNA by PAN2 expression — BLCA

Explore this box plot interactively →