PAN2

Across TCGA cell cohorts, PAN2 mutation is significantly associated with the RNA expression of many other genes, with 237 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAN2-associated genes across cancer lineages are C6orf118, KLHDC3, and GRK4. Each is linked with PAN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAN2-to-partner and partner-to-PAN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by PAN2-low versus PAN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAN2→partner) and Y-score (partner→PAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.088	+2.015	<.001	.005	3	2
LARGE_INTESTINE	KLHDC3 →	+0.536	+3.082	.001	.007	3	2
LARGE_INTESTINE	GRK4 →	+0.493	+2.502	.009	.005	3	2
LARGE_INTESTINE	PRIMPOL →	+0.664	+2.502	<.001	.005	3	2
LARGE_INTESTINE	PIGN →	+0.637	+3.628	.007	<.001	3	2
LARGE_INTESTINE	FBXO48 →	+0.291	+3.082	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 237 associations by consensus.

C6orf118 by PAN2 expression — LARGE_INTESTINE

Explore this box plot interactively →