PAMR1

Across TCGA patient cohorts, PAMR1 mutation is significantly associated with the RNA expression of many other genes, with 2,832 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAMR1-associated genes across cancer lineages are TSEN34, MFN1P1, and LIN7C. Each is linked with PAMR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAMR1-to-partner and partner-to-PAMR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSEN34 grouped by PAMR1-low versus PAMR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAMR1→partner) and Y-score (partner→PAMR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSEN34 →	+0.349	+2.860	.002	.001	3	3
SKCM	MFN1P1 →	+0.012	+1.467	.007	.006	3	2
UCEC	LIN7C →	+0.423	+2.330	.005	<.001	3	2
UCEC	MTA2 →	+0.439	+2.442	<.001	<.001	3	2
UCEC	TIRAP →	+0.429	+3.828	<.001	<.001	3	2
UCEC	CC2D1B →	+0.217	+2.069	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,832 associations by consensus.

TSEN34 by PAMR1 expression — UCEC

Explore this box plot interactively →