PAMR1

Across TCGA patient cohorts, PAMR1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAMR1-associated genes across cancer lineages are mTOR_pS2448, Notch1, and PDCD4. Each is linked with PAMR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAMR1-to-partner and partner-to-PAMR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by PAMR1-low versus PAMR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAMR1→partner) and Y-score (partner→PAMR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.113	-2.102	.025	.016	3	2
UCEC	Notch1 →	+0.131	+1.920	.006	.008	3	2
UCEC	PDCD4 →	-0.496	-1.990	.001	.009	3	2
UCEC	Raptor →	-0.120	-2.222	.020	.010	3	2
UCEC	ATM →	-0.583	-2.137	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.541	+1.926	.007	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

mTOR_pS2448 by PAMR1 expression — UCEC

Explore this box plot interactively →