PAMR1

Across TCGA cell cohorts, PAMR1 mutation is significantly associated with the RNA expression of many other genes, with 365 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAMR1-associated genes across cancer lineages are OR8B4, IFNG, and CST8. Each is linked with PAMR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAMR1-to-partner and partner-to-PAMR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B4 grouped by PAMR1-low versus PAMR1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAMR1→partner) and Y-score (partner→PAMR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR8B4 →	+0.018	+4.562	<.001	<.001	3	2
BLOOD_Leukemia	IFNG →	+0.152	+3.567	<.001	.003	3	1
BLOOD_Leukemia	CST8 →	+0.031	+3.969	<.001	.009	3	1
BLOOD_Leukemia	FRMD1 →	+0.112	+3.263	<.001	.007	3	1
BLOOD_Leukemia	UCMA →	+0.060	+3.926	<.001	.003	3	1
BLOOD_Leukemia	LCE1E →	+0.596	+4.359	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 365 associations by consensus.

OR8B4 by PAMR1 expression — SKIN

Explore this box plot interactively →