Across TCGA cell cohorts, PAM16 protein abundance is significantly associated with the RNA expression of many other genes, with 2,612 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAM16-associated genes across cancer lineages are DNAJC19, AKT1, and RBM23. Each is linked with PAM16 in more than 7 cancer types. Because this analysis shows association rather than direction, both PAM16-to-partner and partner-to-PAM16 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAM16→partner) and Y-score (partner→PAM16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DNAJC19 →	+0.881	+0.648	<.001	<.001	3	8
SKIN	AKT1 →	-0.935	-0.649	.002	<.001	3	7
STOMACH	RBM23 →	-1.220	-0.895	.001	<.001	3	7
BLOOD_Leukemia	SPTAN1 →	-1.087	-0.319	.005	.005	3	6
CNS	EHD1 →	-1.088	-0.642	.001	<.001	3	5
BLOOD_Leukemia	LMF2 →	-0.558	-0.372	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,612 associations by consensus.

Exploration

PAM16 survival (RNA) · tumor vs normal (RNA) · all PAM16 data types