PAM

Across TCGA pan-cancer cohorts, PAM mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PAM’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PAM mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PAM is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

CCRCC, LUAD, and COAD are the cancer types where PAM tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAM mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	II,III,IV	+0.326	<.001	10	view →
LUAD	Male	II,III,IV	+0.536	<.001	8	view →
COAD	Female	II,III,IV	−0.737	<.001	7	view →
HNSC	Male	All	−0.463	<.001	6	view →
LSCC	Male	All	−0.091	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PAM–CCRCC

Open the CCRCC breakdown →