PALMD

Across TCGA pan-cancer cohorts, PALMD Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PALMD data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher PALMD Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PALMD expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, UCEC, and THCA are the cancer types where PALMD Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.106	0.906	<.001	36	view →
UCEC	DFS	Median	All	1.000	0.624	.008	26	view →
THCA	OS	Median	All	0.294	0.945	<.001	22	view →
SKCM	DFS	Median	All	0.311	0.644	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PALMD–BRCA (OS)

Open the BRCA breakdown →