PALMD

Across TCGA pan-cancer cohorts, PALMD mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PALMD data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PALMD mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PALMD expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where PALMD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.352	1.000	.013	20	view →
CCRCC	OS	Quartile	All	0.953	0.695	.007	19	view →
LUAD	DFS	Median	III,IV	0.485	0.995	.003	10	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	6	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	4	view →
LSCC	DFS	Tertile	II,III,IV	0.834	1.000	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PALMD–UCEC (DFS)

Open the UCEC breakdown →