Across TCGA pan-cancer cohorts, PALM3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PALM3 data layer compared with 20 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher PALM3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PALM3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KICH, LIHC, and CESC are the cancer types where PALM3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.161	0.881	<.001	24	view →
LIHC	DFS	Median	All	0.046	0.553	<.001	21	view →
CESC	DFS	Median	II,III,IV	0.140	0.785	<.001	18	view →
UCEC	DFS	Median	All	1.000	0.829	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PALM3 tumor-vs-normal RNA expression · all PALM3 data types