Across TCGA pan-cancer cohorts, PALM3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PALM3 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher PALM3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PALM3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

GBM, LSCC, and LUAD are the cancer types where PALM3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.588	0.865	.003	12	view →
LSCC	OS	Median	All	1.000	0.921	.007	11	view →
LUAD	OS	Median	III,IV	0.670	0.219	.007	8	view →
PDAC	OS	Median	IV	0.425	0.836	.038	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PALM3 tumor-vs-normal RNA expression · all PALM3 data types