Across TCGA patient cohorts, PALM3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PALM3-associated genes across cancer lineages are EGFR_pY1068, ERK2, and MSH2. Each is linked with PALM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PALM3-to-partner and partner-to-PALM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PALM3→partner) and Y-score (partner→PALM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.244	-2.087	.011	.005	3	2
UCEC	ERK2 →	+0.176	+2.700	.017	.006	3	1
UCEC	MSH2 →	-0.232	-3.295	.008	.009	3	1
UCEC	Myosin-IIa_pS1943 →	+0.178	+2.700	.024	.006	3	1
UCEC	Myosin-IIa →	+0.254	+1.814	<.001	.016	3	1
UCEC	N-Ras →	-0.118	-2.074	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

PALM3 survival (RNA) · tumor vs normal (RNA) · all PALM3 data types