PALM

Across TCGA pan-cancer cohorts, PALM mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PALM data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PALM mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PALM expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LUAD, PDAC, and UCEC are the cancer types where PALM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.184	0.862	.002	19	view →
PDAC	OS	Median	IV	0.951	0.381	.006	15	view →
UCEC	DFS	Median	II,III,IV	0.543	0.872	.038	8	view →
HNSC	OS	Tertile	III,IV	0.926	0.748	.029	2	view →
LSCC	DFS	Tertile	II,III,IV	0.587	0.884	.044	2	view →
CCRCC	OS	Median	All	1.000	0.697	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PALM–LUAD (DFS)

Open the LUAD breakdown →