PALM

Across TCGA pan-cancer cohorts, PALM mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PALM’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PALM mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PALM is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and COAD are the cancer types where PALM tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PALM mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−1.309	<.001	12	view →
CCRCC	Female	II,III,IV	−1.289	<.001	12	view →
COAD	Male	All	−1.270	<.001	12	view →
LSCC	Female	All	−1.344	<.001	9	view →
LUAD	Female	II,III,IV	−1.149	<.001	9	view →
OV	All	All	−1.497	<.001	2	view →
PDAC	All	IV	−0.963	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PALM–HNSC

Open the HNSC breakdown →