PALM

Across TCGA patient cohorts, PALM mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PALM-associated genes across cancer lineages are p62 Lck ligand, ATM, and A-Raf_pS299. Each is linked with PALM in more than 1 cancer types. Because this analysis shows association rather than direction, both PALM-to-partner and partner-to-PALM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PALM-low versus PALM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PALM→partner) and Y-score (partner→PALM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.431	+1.884	.002	.030	3	2
UCEC	ATM →	-0.506	-2.986	.010	.035	3	2
UCEC	A-Raf_pS299 →	-0.249	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.268	+3.321	.001	.009	3	1
UCEC	HER3_pY1289 →	+0.088	+2.189	.019	.034	3	1
UCEC	MSH2 →	-0.337	-2.973	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p62 Lck ligand by PALM expression — UCEC

Explore this box plot interactively →