PALM

Across TCGA cell cohorts, PALM mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PALM-associated genes across cancer lineages are CST8, CLDN8, and XAGE3. Each is linked with PALM in more than 1 cancer types. Because this analysis shows association rather than direction, both PALM-to-partner and partner-to-PALM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST8 grouped by PALM-low versus PALM-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PALM→partner) and Y-score (partner→PALM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CST8 →	+0.031	+3.969	<.001	.009	3	1
BLOOD_Leukemia	CLDN8 →	+0.009	+3.234	<.001	.008	3	1
BLOOD_Leukemia	XAGE3 →	+0.079	+3.450	<.001	.004	3	1
BLOOD_Leukemia	OR4D9 →	+0.003	+3.969	<.001	.009	3	1
BLOOD_Leukemia	TPRX1 →	+0.014	+3.475	<.001	.006	3	1
BLOOD_Leukemia	TMEM95 →	+0.018	+3.684	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

CST8 by PALM expression — BLOOD_Leukemia

Explore this box plot interactively →