PALLD

Across TCGA patient cohorts, PALLD mutation is significantly associated with the RNA expression of many other genes, with 5,743 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PALLD-associated genes across cancer lineages are HASPIN, CTNS, and RFC2. Each is linked with PALLD in more than 2 cancer types. Because this analysis shows association rather than direction, both PALLD-to-partner and partner-to-PALLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HASPIN grouped by PALLD-low versus PALLD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PALLD→partner) and Y-score (partner→PALLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HASPIN →	+0.791	+2.925	<.001	<.001	3	3
UCEC	CTNS →	+0.374	+1.743	<.001	<.001	3	3
UCEC	RFC2 →	+0.381	+1.960	<.001	<.001	3	3
UCEC	MTHFD2 →	+0.520	+1.890	.001	.001	3	3
HNSC	RN7SL306P →	+0.209	+4.245	<.001	.008	3	3
UCEC	RPL23AP82 →	+0.481	+2.936	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,743 associations by consensus.

HASPIN by PALLD expression — UCEC

Explore this box plot interactively →