PALLD

Across TCGA patient cohorts, PALLD mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PALLD-associated genes across cancer lineages are C-Raf, ATM, and 4E-BP1_pT37_T46. Each is linked with PALLD in more than 3 cancer types. Because this analysis shows association rather than direction, both PALLD-to-partner and partner-to-PALLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PALLD-low versus PALLD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PALLD→partner) and Y-score (partner→PALLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.155	+2.247	<.001	.001	3	4
UCEC	ATM →	-0.459	-1.947	<.001	<.001	3	3
UCEC	4E-BP1_pT37_T46 →	-0.237	-1.664	.039	.019	3	3
LUAD	FOXO3a_pS318_S321 →	-0.109	-3.000	.025	.035	3	2
UCEC	14-3-3_beta →	-0.102	-3.060	<.001	<.001	3	2
UCEC	eIF4E →	+0.155	+1.947	.016	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

C-Raf by PALLD expression — UCEC

Explore this box plot interactively →