PALLD

Across TCGA cell cohorts, PALLD mutation is significantly associated with the mutation status of many other genes, with 2,767 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PALLD-associated genes across cancer lineages are SLC4A4, ESPL1, and APEH. Each is linked with PALLD in more than 4 cancer types. Because this analysis shows association rather than direction, both PALLD-to-partner and partner-to-PALLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC4A4 grouped by PALLD-low versus PALLD-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PALLD→partner) and Y-score (partner→PALLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC4A4 →	+4.894	+5.870	<.001	<.001	1	5
STOMACH	ESPL1 →	+4.025	+2.942	.009	.009	1	4
LARGE_INTESTINE	APEH →	+4.372	+2.611	<.001	<.001	1	4
SKIN	DNHD1 →	+3.357	+3.532	.005	.005	1	4
BLOOD_Leukemia	MGRN1 →	+4.894	+4.894	.004	.004	1	4
BLOOD_Leukemia	OAS2 →	+4.894	+4.894	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,767 associations by consensus.

SLC4A4 by PALLD expression — BLOOD_Leukemia

Explore this box plot interactively →