PALB2

Across TCGA patient cohorts, PALB2 mutation is significantly associated with the RNA expression of many other genes, with 3,009 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PALB2-associated genes across cancer lineages are HMGB4, RNA5SP432, and SNORA15B-1. Each is linked with PALB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PALB2-to-partner and partner-to-PALB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB4 grouped by PALB2-low versus PALB2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PALB2→partner) and Y-score (partner→PALB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	HMGB4 →	+0.011	+3.891	<.001	.002	3	2
CESC	RNA5SP432 →	+0.201	+4.124	.001	.001	3	2
HNSC	SNORA15B-1 →	+0.564	+3.801	<.001	.009	3	2
SKCM	MIR4440 →	+0.188	+3.140	<.001	.008	3	2
UCEC	MIR5091 →	+0.302	+1.400	.005	.003	3	2
UCEC	DHRS2 →	+0.939	+3.258	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,009 associations by consensus.

HMGB4 by PALB2 expression — CESC

Explore this box plot interactively →