PALB2

Across TCGA cell cohorts, PALB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,401 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PALB2-associated GO terms across cancer lineages are DNA-templated DNA replication, Homologous recombination, and DNA replication. Each is linked with PALB2 in more than 12 cancer types. Because this analysis shows association rather than direction, both PALB2-to-partner and partner-to-PALB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by PALB2-low versus PALB2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PALB2→partner) and Y-score (partner→PALB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA-templated DNA replication →	+0.128	+0.792	<.001	<.001	3	13
BREAST	Homologous recombination →	+0.092	+0.743	<.001	<.001	3	12
BLOOD_Lymphoma	DNA replication →	+0.092	+0.692	<.001	<.001	3	12
BLOOD_Myeloma	Replication fork processing →	+0.120	+0.713	<.001	.004	3	12
BREAST	Mitotic recombination →	+0.094	+0.670	<.001	.001	3	12
LUNG_SCLC	Response to hydroxyurea →	+0.127	+0.497	.001	.006	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,401 associations by consensus.

DNA-templated DNA replication by PALB2 expression — BLOOD_Myeloma

Explore this box plot interactively →