PALB2

Across TCGA cell cohorts, PALB2 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PALB2-associated genes across cancer lineages are FGF6, APOBEC1, and SEMG2. Each is linked with PALB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PALB2-to-partner and partner-to-PALB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF6 grouped by PALB2-low versus PALB2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PALB2→partner) and Y-score (partner→PALB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FGF6 →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Myeloma	APOBEC1 →	+0.023	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SEMG2 →	+0.023	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CEACAM8 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR5K4 →	+0.023	+4.807	<.001	.006	3	1
URINARY_TRACT	HTN1 →	+0.157	+4.044	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

FGF6 by PALB2 expression — BLOOD_Myeloma

Explore this box plot interactively →